5/5/15

Advances in Immunology

    Using the analogy of a spring, a book published by Oxford University Press called Healthier Societies: From Analysis to Action describes the human immune system in the following way:

If a spring is “sprung” too often over time, it will start to lose its “elasticity”, and, thus its ability to return to the original shape after being stretched. If the immune system is too frequently and severely challenged over time…this process may prematurely age the system leading to “dysregulation.1 [emphasis mine]

     The human immune system is comprised of 2 trillion cells and has two components: an innate system and an adaptive system. Dr. Donald Miller, Professor of Surgery at the University of Washington explains that common infectious diseases of childhood play an essential role in the maturation of the adaptive immune system.
2  The adaptive immune system is managed by two types of helper-T cells: cellular T-cells (Th1); and humoral T-cells (Th2). Proper development of the adaptive immune system depends on stimulation of both Th1 and Th2 components of this system in relative balance. 1 3  Overstimulation of the Th2 component of the adaptive immune system has been associated with various autoimmune conditions and diseases of immune dysregulation. 1 3 4

    While natural exposure to common diseases of childhood (like measles, mumps, rubella and chickenpox) stimulate both the Th1 and Th2 components of the adaptive immune system, vaccines stimulate primarily the Th2 component which has the effect of both increasing Th2 development and inhibiting Th1 development.3 4  Because vaccines stimulate the adaptive immune system in an unbalanced way, many scientists and doctors are beginning to make the connection between overstimulation of the Th2 side of the immune system early in life by vaccines, and a wide array of immune dysfunctions and even cancer. Given that Th1 cells are essential in protecting against cancer, mechanisms that compromise the development of the Th1 side of the immune system (including vaccines) are suspected of increasing susceptibility to developing cancer later in life.2 

    The Th2 component of the adaptive immune system is primarily concerned with the production of antibodies. Vaccines appear to be very good at generating antibodies (at least in the short-term) but do increased antibody levels necessarily mean ‘protection’? Contrary to the long-held belief that antibodies are essential for protection against infectious diseases, a recent study finds not only that high antibody levels do not necessarily confer protection, but that antibodies are in fact not required for protection against some viruses. A 2012 study published in Immunity Journal found that when mice were infected with vesicular stomatitis virus, antibodies are neither needed nor sufficient for protection.”5 The results of this and other similar studies suggest that the immunological mechanisms underlying protection from infectious diseases are far more complex than previously believed.

References:

1.      https://books.google.com/books?id=tiStrZDze54C&pg=PA40&lpg=PA40&dq=overstimulation+of+th2+and+immune+dysregulation&source=bl&ots=Yqm4sVus7X&sig=SSLKH4_Cq5-dNTJ7g5zPr3MLNtI&hl=en&sa=X&ei=wVo-VTXzy7AEkpyB2AY&sqi=2&ved=0CCwQ6AEwAg#v=onepage&q=overstimulation%

2.       https://www.lewrockwell.com/2015/02/donald-w-miller-jr-md/more-dangerous-than-measles/

3.       www.the-scientist.com/?articles.view/articleNo/13377/title/Distinguishing-Th1-and-Th2-Cells/

4.       http://www.invivogen.com/review-vaccine-adjuvants

5.       http://www.cell.com/immunity/abstract/S1074-7613%2812%2900057-X?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS107476131200057X%3Fshowall%3Dtrue&cc=y=



        

 

 

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