A Voice For Vaccine Realism

5/15/15

Introduction

We are told that the risk of suffering a serious adverse reaction to a vaccine is very small. This appears to be true. Suppose it is true that the risk of suffering a serious adverse reaction to one vaccine is very small, but why should we frame the overall risk of vaccination in terms of a singular vaccine when in fact, the current CDC Immunization Schedule lists 69 vaccine doses before age 18?2 In light of the exponential growth of the Immunization Schedule over the past several decades, perhaps it is more appropriate to consider vaccination in terms of the cumulative risks and effects of receiving multiple injections of viruses, bacteria and toxic chemicals (the likes of which include mercury, aluminum, formaldehyde and polysorbate 80) during the most critical periods for brain and immune system development.1 2 3 4

Currently, all 50 states require vaccinations for children upon entering public school.5 As such, children in America today are scheduled to risk vaccine injury 49 times before they are 6 years old (28 shots containing 49 vaccine doses). That's more than double the number of vaccine doses recommended in 1983. In fact, the United States immunization schedule stipulates more vaccine doses for infants aged less than one year than any other country in the world. Meanwhile, the U.S. ranks lower on infant mortality rate than 26 other industrialized countries. 6

Not only do children take the risks of each vaccine individually, they are systematically coerced and in some cases legally obligated to undertake the cumulative risks of the most updated version of the Childhood Immunization Schedule, the safety of which has never been tested.

A one-size-fits-all approach to vaccination is not safe or effective, as the emerging field of “Vaccinomics” proves that individual responses to vaccines are as complex and varied as people.7 While scientists are making new discoveries about the underlying genetic and environmental factors that predispose inadequate vaccine response and (potentially fatal) adverse vaccine reactions, the one-size-fits-all application of the current vaccine program is failing to assimilate these discoveries.

The CDC, public health officials and many doctors would have parents believe that there isn’t time to research vaccination before making a decision (the implication being that their children will most likely die from an infectious disease in the interim) but this is simply not true. Vaccination is a medical intervention. It is important that we make medical decisions for our children from a place of knowledge rather than irrational fear.

There is no right or wrong choice to make about vaccination but the best choice is an informed one. This means understanding the risks and the benefits of vaccination, infectious diseases and performing an individualized risk-benefit analysis for each one. The information provided here should not be used as advice, but rather as a guide for enhancing your understanding of the risks and responsibility that come with either choice. The resources located on the right and left-hand sides of this page can serve as a starting point for those interested in learning more about the risks, limitations and legal considerations of vaccination in America.

References:

1. http://www.cdc.gov/vaccines/schedules/downloads/child/0-18yrs-schedule.pdf

2. http://www.nvic.org/CMSTemplates/NVIC/pdf/49-Doses-PosterB.pdf

3. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf

4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737431/

5. http://vaccines.procon.org/#did_you_know

6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170075/

7. http://www.niaid.nih.gov/topics/vaccines/Documents/JordanReport2012.pdf

5/14/15

Studies Show Disturbing Relationship Between Vaccines and Infant Mortality

In 2011, GlaxoSmith Kline (GSK) issued a confidential report to the Regulatory Authority stating that at least 68 babies had died within 20 days of receiving Infanrix hexa, a multivalent vaccine combining 6 different disease antigens. An Italian Court Justice ordered that the report be made public and it is now available for online viewing.1 2 (See Figure 1) GSK stated that the deaths were attributed to Sudden Infant Death Syndrome (SIDS) and Sudden Unexpected Infant Death Syndrome (SUDS), assuring that there is no reason to believe the deaths were related to the vaccine.

Figure 1. GlaxoSmith Kline’s report to Regulatory Authority showing SIDS deaths following Infanrix hexa.

Upon further examination however, Dr. Jacob Puliyel, head of Pediatrics at St. Stephen’s Hospital found that 97% of the SIDS deaths occurred within the first 10 days following receipt of Infanrix hexa and only 3% occurred within the second 10 day period. If the deaths had been ‘coincidental SIDS deaths,’ Dr. Puliyel explains that the distribution of deaths across the first and second 10 day periods should have been relatively the same.2

According to the CDC, SIDS “is the third leading cause of infant deaths in the United States.”3 Interestingly, SIDS is listed as an “Adverse Reaction” to Prevnar 13 (Pneumococcal 13-valent Conjugate) vaccine and the CDC’s own study found 29,747 adverse events reported following receipt of Haemophilus Influenzae Type b (Hib) vaccine, 384 of which were deaths attributed to SIDS. The CDC maintains that the cause of SIDS is a total mystery.4 5

While there are many factors that influence infant mortality rates and the above studies alone do not prove causation, the relationship between infant mortality (specifically SIDS) and routine vaccine doses clearly warrants further investigation.

References:

1. https://autismoevaccini.files.wordpress.com/2012/12/vaccin-dc3a9cc3a8s.pdf

2. http://www.inquisitr.com/1751130/doctor-claims-that-hexavalent-infanrix-vaccine-causes-sudden-death-of-babies-anti-vaccination-advocates-question-why-report-was-confidential/

3. http://www.cdc.gov/sids/aboutsuidandsids.htm

4. http://www.fda.gov/downloads/biologicsbloodvaccines/vaccines/approvedproducts/ucm201669.pdf

5. http://www.ncbi.nlm.nih.gov/pubmed/25598306

5/12/15

Vaccines as Mechanism of Aluminum Toxicity

The purpose of vaccine adjuvants is to optimize the body’s immune response to vaccine antigens but these substances are not without risks and side effects. Aluminum is a naturally occurring metal, a known human toxin and the most commonly used vaccine adjuvant. Aluminum compounds, specifically aluminum salts are the main adjuvants approved for use in human vaccines.1 2 3

According to MedScape,

“Aluminum is absorbed…parenterally4 [this means administered by injection] via immunizations [vaccines]...If a significant aluminum load exceeds the body's excretory capacity, the excess is deposited in various tissues, including bone, brain, liver, heart, spleen, and muscle. This accumulation causes morbidity and mortality through various mechanisms.”5 [emphasis mine]

Calcium Inhibition

Aluminum is known to disrupt the body’s absorption of calcium, an essential mineral for bone and brain cell development.6 So important is the role of calcium to brain development that calcium deficiency during early life stages is associated with central nervous system diseases like autism and mental retardation.7 By disrupting calcium absorption, aluminum not only interferes with proper brain development, it is also associated with various bone diseases and is particularly hazardous to individuals of compromised physiological function.8 According to the Handbook for Toxicology of Metals, “Reduced renal [kidney] function markedly increases the risk of aluminum accumulation.”9 [emphasis mine]

In 2001, the FDA corroborated this fact by amending its regulation of aluminum content in large and small volume parenteral drug products (intravenous drugs and nutrition). In doing so, the FDA cited several studies 10 demonstrating a positive relationship between aluminum accumulation and various central nervous system (CNS) and bone diseases. The FDA document states,

“Generally, when medication and nutrition are administered orally, the gastrointestinal [GI] tract acts as an efficient barrier to the absorption of aluminum, and relatively little ingested aluminum actually reaches body tissues. However, parenterally administered drug products containing aluminum bypass the protective mechanism of the gastrointestinal tract and aluminum circulates and is deposited in human tissues...Research indicates that neonates [infants] and patient populations with impaired kidney function may be at high risk of exposure to unsafe amounts of aluminum…patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 microg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.”11 [emphasis mine]

While this document’s purpose is to amend aluminum regulations for intravenous drugs and nutrition products, the FDA’s statements regarding aluminum accumulation from parenterals make it clear that parenterally administered aluminum exceeding 4-5mcg/kg/day is associated with CNS and bone diseases. Perhaps this is because when aluminum is injected into the body (bypassing the protective barrier of the GI tract) 100 percent of the aluminum circulates in the body making it more readily absorbed by human tissues, including but not limited to the bones and brain.3

As a 2013 study published by Kahn et al in BioMed Central Journal finds,

“Intramuscular injection of alum-containing vaccine was associated with the appearance of aluminum deposits in distant organs, such as spleen and brain where they were still detected one year after injection.”12 [emphasis mine]

Kahn et al conclude,

“Alum has high neurotoxic potential, and planning administration of continuously escalating doses of this poorly biodegradable adjuvant in the population should be carefully evaluated by regulatory agencies since the compound may be insidiously unsafe. It is likely that good tolerance to alum may be challenged by a variety of factors including overimmunization, BBB [blood-brain barrier] immaturity, individual susceptibility factors, and aging…”12 [emphasis mine]

Infant Renal Function

Clearly aluminum compounds can be hazardous to the human system, particularly when administered by means of injection and especially if the individual has reduced or impaired kidney function. Upon further research on the role the kidneys play in excretion of aluminum from the body, what I discovered about the renal status of infants implies dismal outcomes for infants receiving injections of aluminum.

Glomerular filtration rate (GFR) is a measure used to assess proper kidney function. When reported GFR is below 90ml/min/1.73 m, the individual is said to have "reduced or impaired kidney function.” According to a text book entitled, "Essentials in Pediatric Urology",

"The kidney regulates homeostasis by two fundamental functions, the glomerular and the tubular. In neonates both functions are deficient and although the neonatal kidneys are well equipped to sustain physiological processes, they are severely limited in their response to stress. Neonates have glomerular filtration rate (GFR) as low as 20ml/min/1.73 m2 at birth, which rises gradually to reach the adult rates at 18 months. Additionally, due to immature tubular function, neonates have reduced concentrating capacity, negative sodium equilibrium and reduced bicarbonate levels and they are, thus, prone to dehydration and hyponatremia….in a healthy term neonate the GFR at birth is just 20 ml/min/1.73m and about 10-15 ml/min/1.73m in a premature one. This low GFR limits all renal functions, especially with regard to water and electrolyte homeostasis and the excretion of waste products. During the first month of life GFR increases rapidly due to a rise of systemic BP and a concomitant fall in renal vascular resistance, but it hardly exceeds 40ml/min/1.73m in the term neonate."13 [emphasis mine]

Taking the information about neonatal kidney function from the urology text above along with the information from Figure 2, a healthy full term infant at birth is described as having "severely reduced kidney function," and at one month old, the infant is described as having "moderately reduced kidney function."13 14 With credible academic and medical sources indicating that infant GFR is equivalent to that of a person with moderate to severely reduced kidney function, I find it unconscionable that the FDA does not explicitly warn the public that infants are in a high-risk category for aluminum accumulation and are therefore not good candidates for any vaccine containing aluminum.

Figure 2. GFR ranges and associated renal status.

Stage of Chronic Kidney Disease	eGFR ml/min/1.73 m
Stage 1: the eGFR shows normal kidney function but you are already known to have some kidney damage or disease. For example, you may have some protein or blood in your urine, an abnormality of your kidney, kidney inflammation, etc.	90 or more
Stage 2: mildly reduced kidney function AND you are already known to have some kidney damage or disease. People with an eGFR of 60-89 without any known kidney damage or disease are not considered to have chronic kidney disease (CKD).	60-90
Stage 3: moderately reduced kidney function. (With or without a known kidney disease. For example, an elderly person with ageing kidneys may have reduced kidney function without a specific known kidney disease.) GFR for full-term infants at one month (<40 ml/min/1.73²)	45 to 59 (3A) 30 to 44 (3B)
Stage 4: severely reduced kidney function. (With or without known kidney disease.) GFR for full-term infants at birth (20 ml/min/1.73²)	15 to 29
Stage 5: very severely reduced kidney function. This is sometimes called end-stage kidney failure or established renal failure. GFR for premature infants (10-15 ml/min/1.73²)	Less0 than 15

How Much is Safe?

Aluminum adjuvant can be found in the following common childhood vaccines: Infanrix DTaP, Pediarix (DTaP

-Hepatitis B-Polio combination), Pentacel (DTaP-HIB-Polio combination), Hepatitis A, Hepatitis B, Haemophilus influenzae B (HIB), Human Papilloma Virus (HPV), and Pneumococcal.15 16 17 18 19 20 21 22

Let's say your baby weighs around 7lbs at birth. That's roughly 3.25 kilograms. As per the FDA's suggested safe amount of aluminum from parenterals, your 7lb baby could receive up to 16.25mcg parenteral aluminum in one day. According to this product insert for GlaxoSmithKline's Hep B vaccine, the infant dose of ENGERIX (recommended by the CDC to be administered to every infant within hours of birth) contains 0.25 milligrams (mg) of aluminum. Translation: 250 micrograms (mcg). That’s more than 15 times the FDA’s standard of <5mcg/kg/day. Figure 3 shows all CDC recommended vaccine doses containing aluminum between birth and 2 years.

Figure 3.

Vaccine	Time of Administration	Aluminum Content (mcgs)	Total Aluminum Count (mcgs)
Hep B (Engerix)	Birth	250	250
Hep B (Engerix)	1-2 months	250	500
Heb B (Engerix)	6-18 months	250	750
Hep A (Havrix)	>12 months	250	1,000
Hep A (Havrix)	< 23 months	250	1,250
Haemophilus influenza type b (PedvaxHib)	> 2 months	225	1,475
Haemophilus influenza type b (PedvaxHib)	Between 2 and 15 months	225	1,700
Haemophilus influenza type b (PedvaxHib)	< 15 months (with suggested 4^th dose)	225	1,925
Pneumococcus (PVC-13)	> 2 months	125	2,050
Pneumococcus (PVC-13)	Between 2-15 months	125	2,175
Pneumococcus (PVC-13)	Between 2-15 months	125	2,300
Pneumococcus (PVC-13)	< 15 months	125	2,425
Diptheria/tetanus/acelluar pertussis (DTaP)	> 2 months	625	3,050
Diptheria/tetanus/acelluar pertussis (DTaP)	Between 2-18 months	625	3,675
Diptheria/tetanus/acelluar pertussis (DTaP)	Between 2-18 months	625	4,300
Diptheria/tetanus/acelluar pertussis (DTaP)	< 18 months	625	4,925

Before a child in America turns 2 years old, he/she is looking at a grand total of around 4,925 mcg parenterally administered aluminum from vaccines. This is a conservative estimate as some variations and combinations of vaccines contain more aluminum than others. Keeping in mind that many of these vaccines are routinely given at one doctor visit, it is possible that your child could receive in excess of 1,000mcg parenteral aluminum in one day.

References:

1. http://www.medilexicon.com/medicaldictionary.php?t=1338

2. http://www.arltma.com/Articles/AlumToxDoc.htm

3. http://www.meerwetenoverfreek.nl/images/stories/Tomljenovic_Shaw-CMC-published.pdf

4. http://medical-dictionary.thefreedictionary.com/parenteral

5. http://emedicine.medscape.com/article/165315-overview

6. http://web.mit.edu/athletics/sportsmedicine/wcrminerals.html

7. http://cshperspectives.cshlp.org/content/3/10/a004259.full

8. http://www.ncbi.nlm.nih.gov/pubmed/11904354

9. https://books.google.com/books?id=ZFxzAwAAQBAJ&pg=PA553&lpg=PA553&dq=aluminum+is+about+90+percent+bound+in+plasma&source=bl&ots=AKt9s9CMdZ&sig=mYzeK59y2N-mypzQh7VWTFvh_WE&hl=en&sa=X&ei=1AszVY3iNJPqgwS97IDYBg&ved=0CC4Q6AEwAg#v=onepage&q=aluminum%20is%20abou&f=false

10. http://www.gpo.gov/fdsys/pkg/FR-1998-01-05/pdf/98-76.pdf

11. http://www.fda.gov/OHRMS/DOCKETS/98fr/012600b.txt